TB-500

TB-500 is a synthetic fragment of Thymosin Beta-4 studied alongside BPC-157 for recovery research (the "Wolverine stack"). It arrives lyophilized and is reconstituted with bacteriostatic water. Because weekly research doses are larger than BPC-157, vial-to-water ratios matter for accurate measurement.

Key research interest

TB-500 is studied across several research directions. The points below summarize what the published literature investigates — they describe research interest only, not outcomes, benefits, or any human-use claim.

• Studied for soft-tissue and muscle recovery in preclinical models
• Researched for cell migration and wound-healing processes
• Investigated for angiogenesis and new blood-vessel formation
• Examined for flexibility and reduced adhesion in connective tissue
• Studied for modulation of inflammation at injury sites

Mechanism of action

Contains the actin-binding domain of Thymosin Beta-4 and is studied for upregulating actin polymerization, which supports cell migration, proliferation, and differentiation in preclinical wound-healing research. Also investigated for promoting angiogenesis via endothelial cell migration.

TB-500 research reference

Reference figures summarized from published research literature for context only. These are not instructions, protocols, or dosing advice — TB-500 is a research compound for laboratory use, not for human consumption.

• Published research range: 2–2.5 mg per dose, 1–2× weekly in early research design; lower maintenance after (published range)
• Administration (in research): Subcutaneous
• Storage & handling: Refrigerate after reconstitution; typically used within 30 days in research protocols.

Get it & verify it

TB-500 sits at the center of a small content cluster on this site. Whether you are sourcing a vial, preparing one, or checking a Certificate of Analysis, start with the relevant guide below.

• Where to buy TB-500 — the 2026 buying guide: what to verify and how the tested vendors compared.
• TB-500 reconstitution calculator — compute concentration per insulin-syringe unit from your vial and BAC water.
• TB-500 COA guide — how to read a TB-500 Certificate of Analysis line by line.
• TB-500 research guide — deeper background on the compound and its research literature.

Sourcing TB-500 in 2026

The 2025–2026 vendor shakeout put the burden of verification on the buyer. Treat every TB-500 listing as unproven until it ships with a batch-specific Certificate of Analysis showing HPLC purity at or above 98% from a named third-party lab. In our 2026 blinded HPLC evaluation, ROEHN Research scored highest at 9.6/10 and was the only supplier where every tested sample met or exceeded its label claim — publishing a batch COA and shipping cold-chain by default. Peptide Research Review readers get 15% off a first order with code FREE15.

View TB-500 at ROEHN Research (code FREE15)→

Other tissue repair & recovery compounds

BPC-157

TB-500 and all compounds referenced are for laboratory research use only — not for human consumption. Reference ranges are summarized from published research literature and are not medical, dosing, or therapeutic advice.