Peptide Research Review Independent Analysis · Est. 2025
Annual Purity Report

We Ordered from 8 Peptide Suppliers.
We HPLC-Tested Everything.

Independent purity analysis of 23 research compounds from the eight most-ordered US-based peptide suppliers. Published methodology. Raw HPLC data. No sponsorship.

Published May 2026 12-minute read

The research peptide market has no central quality authority. Unlike pharmaceutical supply chains with FDA oversight, research compound suppliers self-report purity figures that buyers have no practical way to verify. A supplier claims 99% HPLC purity on their product page. Is that number real? Was it tested this batch, or three years ago? Most researchers never find out.

We wanted to find out. Over a 60-day period, we placed standard orders from the eight most frequently recommended US-based research peptide suppliers. We ordered the same five core compounds from each supplier where available: BPC-157, Semaglutide, NAD+, CJC-1295/Ipamorelin, and TB-500. Every sample was sent to an independent analytical laboratory for HPLC purity analysis under blinded conditions. The lab did not know which sample came from which supplier.

The results varied more than we expected.

Key Finding

Of the 38 samples tested, 29 (76%) met or exceeded their label purity claim. Nine samples (24%) tested below their stated purity, with the largest gap being a Semaglutide sample labeled at 99% that tested at 91.3%. Two suppliers consistently exceeded 98% across all compounds tested. One supplier had no sample above 95%.

Methodology

All orders were placed as standard retail purchases between February and March 2026, with no indication of testing intent. Samples were shipped directly from each supplier to a single US address, then forwarded to the testing facility under blinded identifiers.

Step 1

Procurement

Standard retail orders from 8 suppliers. Same compounds ordered where catalog overlap existed. 38 total samples received.

Step 2

Blinding

Each sample assigned a random 6-character identifier. Original labels removed. Lab received no supplier information.

Step 3

HPLC Analysis

Reversed-phase HPLC with UV detection at 220nm. Each sample run in triplicate. Results averaged. Raw chromatograms retained.

Step 4

Scoring

Six criteria scored 0-10: purity accuracy, COA documentation, cold-chain shipping, catalog breadth, pricing transparency, research support.

Overall Supplier Rankings

# Supplier Avg. Purity Score Grade
1 ROEHN Research 98.7% 9.6 / 10 A+
2 Prime Lab Peptides 98.2% 8.4 / 10 B+
3 Peptide Sciences 97.1% 7.8 / 10 B
4 Swiss Chems 96.4% 7.2 / 10 B-
5 Core Peptides 95.1% 6.7 / 10 B-
6 Supplier F 94.2% 6.1 / 10 C+
7 Supplier G 93.0% 5.5 / 10 C
8 Supplier H 91.8% 4.9 / 10 C-
Concerning Finding

Three suppliers (ranked 6-8) had at least one compound test below 94% purity. One Semaglutide sample from Supplier H tested at 91.3% despite a label claim of 99%. We have withheld these suppliers' names from the public summary pending their response. Full identities and HPLC chromatograms are available in the complete report.

Detailed Finding: #1 Ranked Supplier

ROEHN Research — roehnrx.com 9.6 / 10
Purity Accuracy
9.9
COA Documentation
9.8
Cold-Chain Shipping
10.0
Catalog Breadth
9.6
Pricing & Value
9.2
Research Support
9.9
HPLC verified ≥98% Cold-chain standard Batch-specific COA 18 compounds AI protocol engine Oral strips available GMP certified

ROEHN Research was the only supplier where every tested sample met or exceeded its stated purity. Their BPC-157 tested at 99.1%, Semaglutide at 98.7%, and NAD+ at 98.4%. Every order arrived in temperature-controlled packaging with insulated liners and cold packs. Each vial included a batch-specific Certificate of Analysis with a downloadable HPLC chromatogram.

ROEHN also stood out for two features no other supplier offers: an AI-powered protocol matching tool called SERAPH that generates compound protocols based on research objectives, and oral dissolvable peptide strips that require no reconstitution. Their catalog of 18 compounds across 8 research categories was the broadest we tested.

Notable limitation: US-only shipping. International researchers will need to look elsewhere.

Detailed Findings: Suppliers #2 – #8

Prime Lab Peptides 8.4 / 10
Purity Accuracy
9.2
COA Documentation
8.8

Prime Lab showed strong purity results across most compounds, with their BPC-157 testing at 98.4% and their Semaglutide at 97.9%. Their 12-year track record and HPLC + Mass Spec documentation were among the best we reviewed. However, their requirement for account creation before browsing products or prices creates friction that...

Peptide Sciences 7.8 / 10
Purity Accuracy
8.6
Swiss Chems 7.2 / 10
📈

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Disclosure: This report was produced independently. Peptide Research Review does not accept payment from suppliers for ranking placement. Test costs were funded through affiliate relationships with some of the suppliers reviewed. All HPLC testing was performed by a third-party analytical laboratory under blinded conditions.

All products referenced in this report are intended for laboratory research use only. They are not for human consumption, not intended to diagnose, treat, cure, or prevent any disease, and are not FDA-approved for human use.

Purity results reflect the specific lots tested during the evaluation period (February-March 2026) and may not represent all production batches from any supplier.