NAD+

NAD+ is studied in cellular-aging and longevity research. It ships lyophilized in large vials (100–500 mg) and is reconstituted with bacteriostatic water. NAD+ is hygroscopic and degrades faster than most peptides, so supplier cold-chain shipping and post-reconstitution storage matter more here.

Key research interest

NAD+ is studied across several research directions. The points below summarize what the published literature investigates — they describe research interest only, not outcomes, benefits, or any human-use claim.

• Studied for mitochondrial function and cellular energy metabolism
• Researched for DNA-repair and genomic-stability pathways
• Investigated for sirtuin-enzyme activation linked to aging research
• Examined for cellular redox balance and NAD+/NADH ratios
• Studied for neuronal and metabolic resilience in preclinical models

Mechanism of action

A central coenzyme in redox reactions and a substrate for sirtuins and PARP enzymes. Research investigates its role in restoring intracellular NAD+ pools to support mitochondrial energy production, sirtuin-mediated deacetylation, and DNA-repair signaling implicated in cellular-aging pathways.

NAD+ research reference

Reference figures summarized from published research literature for context only. These are not instructions, protocols, or dosing advice — NAD+ is a research compound for laboratory use, not for human consumption.

• Published research range: 100–500 mg per dose, daily or alternating days (published research range)
• Administration (in research): Subcutaneous or intramuscular
• Storage & handling: Most thermally fragile compound here. Refrigerate; typically used within 14 days reconstituted.

Get it & verify it

NAD+ sits at the center of a small content cluster on this site. Whether you are sourcing a vial, preparing one, or checking a Certificate of Analysis, start with the relevant guide below.

• Where to buy NAD+ — the 2026 buying guide: what to verify and how the tested vendors compared.
• NAD+ reconstitution calculator — compute concentration per insulin-syringe unit from your vial and BAC water.
• NAD+ COA guide — how to read a NAD+ Certificate of Analysis line by line.
• NAD+ research guide — deeper background on the compound and its research literature.

Sourcing NAD+ in 2026

The 2025–2026 vendor shakeout put the burden of verification on the buyer. Treat every NAD+ listing as unproven until it ships with a batch-specific Certificate of Analysis showing HPLC purity at or above 98% from a named third-party lab. In our 2026 blinded HPLC evaluation, ROEHN Research scored highest at 9.6/10 and was the only supplier where every tested sample met or exceeded its label claim — publishing a batch COA and shipping cold-chain by default. Peptide Research Review readers get 15% off a first order with code FREE15.

View NAD+ at ROEHN Research (code FREE15)→

Other longevity & cellular compounds

GHK-Cu

NAD+ and all compounds referenced are for laboratory research use only — not for human consumption. Reference ranges are summarized from published research literature and are not medical, dosing, or therapeutic advice.