Melanotan II

Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone studied in pigmentation research. It ships lyophilized and is reconstituted with bacteriostatic water. Research doses are in the small microgram range, so accurate concentration math is critical.

Key research interest

Melanotan II is studied across several research directions. The points below summarize what the published literature investigates — they describe research interest only, not outcomes, benefits, or any human-use claim.

• Studied for stimulation of melanin production (melanogenesis)
• Researched for skin-pigmentation responses in animal models
• Investigated for melanocortin-receptor signaling effects
• Examined for influence on appetite and food intake
• Studied for sexual-behavior endpoints via central melanocortin pathways

Mechanism of action

A non-selective agonist of melanocortin receptors (notably MC1R and MC4R). MC1R activation is studied for stimulating melanin synthesis in melanocytes, while MC4R activity in the brain is investigated for effects on appetite and sexual-arousal pathways.

Melanotan II research reference

Reference figures summarized from published research literature for context only. These are not instructions, protocols, or dosing advice — Melanotan II is a research compound for laboratory use, not for human consumption.

• Published research range: Loading then maintenance; published research uses small mcg-range doses (research range)
• Administration (in research): Subcutaneous
• Storage & handling: Refrigerate after reconstitution; used within 30 days in most research protocols.

Get it & verify it

Melanotan II sits at the center of a small content cluster on this site. Whether you are sourcing a vial, preparing one, or checking a Certificate of Analysis, start with the relevant guide below.

• Where to buy Melanotan II — the 2026 buying guide: what to verify and how the tested vendors compared.
• Melanotan II reconstitution calculator — compute concentration per insulin-syringe unit from your vial and BAC water.
• Melanotan II COA guide — how to read a Melanotan II Certificate of Analysis line by line.

Sourcing Melanotan II in 2026

The 2025–2026 vendor shakeout put the burden of verification on the buyer. Treat every Melanotan II listing as unproven until it ships with a batch-specific Certificate of Analysis showing HPLC purity at or above 98% from a named third-party lab. In our 2026 blinded HPLC evaluation, ROEHN Research scored highest at 9.6/10 and was the only supplier where every tested sample met or exceeded its label claim — publishing a batch COA and shipping cold-chain by default. Peptide Research Review readers get 15% off a first order with code FREE15.

View Melanotan II at ROEHN Research (code FREE15)→

Other other research compounds compounds

PT-141

Melanotan II and all compounds referenced are for laboratory research use only — not for human consumption. Reference ranges are summarized from published research literature and are not medical, dosing, or therapeutic advice.