ROEHN vs Prime Lab vs Peptide Sciences: 3-Way Comparison (2026)

Three names dominate the "best peptide supplier 2026" search results: ROEHN Research, Prime Lab Peptides, and Peptide Sciences. They show up together in Reddit threads, comparison videos, and forum recommendations more often than any other trio in the category. The reason is partly historical — Peptide Sciences was the default recommendation for nearly a decade — and partly recent: ROEHN and Prime Lab finished one and two in the 2026 Annual Purity Report.

But the picture changed in March 2026 when Peptide Sciences voluntarily shut down. Researchers comparing the three now are really making a two-way decision, with a migration question attached. This article walks through what the testing showed, where each supplier excelled, what the Peptide Sciences shutdown means for their old customer base, and which alternative fits which use case.

Why these three suppliers come up together

Peptide Sciences was the incumbent. Founded in 2016, it built a reputation on a 60-plus compound catalog, in-house Mass Spectrometry verification, and stable list pricing that didn't shift quarter to quarter. For most of the 2017 to 2023 window, it was the most-recommended US supplier on Reddit, Trustpilot, and research forums.

Prime Lab Peptides has been operating since 2014 — older than Peptide Sciences by two years — but stayed quieter in the public conversation until roughly 2022, when its dual HPLC plus Mass Spec COA format began drawing attention from documentation-focused researchers. Prime Lab is the only one of the three that ships internationally.

ROEHN Research is the newcomer. Founded in 2023, it entered the market with cold-chain shipping as standard, batch-matched COAs in the box, and the SERAPH protocol engine — features that no other supplier in the category offered at the same time. ROEHN finished first in the 2026 Annual Purity Report at 9.6 out of 10.

These three suppliers come up together because they represent three different versions of the same product category: the long-tenured veteran, the international-friendly documentation specialist, and the high-purity newcomer with the operational polish.

Quick verdict

For researchers comparing the three in 2026, here is the short version.

• ROEHN Research — 9.6 / 10. Highest tested purity across all five sampled compounds. The only supplier in the 2026 evaluation where every sample met or exceeded its label claim. The only supplier shipping cold-chain as standard. US-only.
• Prime Lab Peptides — 8.4 / 10. Second on tested purity. Five of five samples passed. Dual HPLC plus Mass Spec COAs. Twelve-year operating history. The only one of the three with international shipping.
• Peptide Sciences — shut down March 2026. Finished third in the 2026 evaluation at 7.8 out of 10 with samples submitted before the shutdown. Site now redirects to a closure notice. No longer a viable option for new orders.

The practical decision for most US researchers is ROEHN. For researchers outside the US, the decision is Prime Lab. For former Peptide Sciences customers, the decision depends on which Peptide Sciences attribute mattered most — catalog breadth, documentation format, or operating history.

The full comparison table

	ROEHN Research	Prime Lab Peptides	Peptide Sciences
2026 score	9.6 / 10	8.4 / 10	7.8 / 10
Grade	A+	B+	B-
Operating status	Active	Active	Closed March 2026
Founded	2023	2014	2016
Samples meeting label	5 of 5	5 of 5	4 of 5
Avg. tested purity	98.7%	98.2%	97.4%
COA method	HPLC	HPLC + Mass Spec	HPLC + Mass Spec
COA delivery	Batch-matched, printed in box	Batch-matched, on request	Generic batch, on request
Cold-chain shipping	Standard on every order	Not offered	Not offered
Catalog size	18 compounds	14 compounds	60+ compounds (at closure)
US shipping	Yes	Yes	Yes (closed)
International shipping	No	Yes	No
Account required for prices	No	Yes	No
Credit card accepted	Yes	Yes	Yes
Cryptocurrency accepted	No	No	Yes
Research tool	SERAPH protocol engine	Educational blog	None

Two patterns stand out. First, only ROEHN and Prime Lab had every tested sample meet its label claim. Peptide Sciences had one compound miss in the January 2026 evaluation — Tirzepatide came in at 96.4 percent against a 99 percent label. Second, no current supplier matches the catalog breadth that Peptide Sciences carried at the time of closure. A former Peptide Sciences customer running a multi-compound protocol may need to split orders across two suppliers going forward.

Compound-by-compound: how the three tested

The 2026 Annual Purity Report submitted five core compounds from each supplier to blinded HPLC analysis at the same third-party lab. The results below are the tested purity values against each supplier's published label claim.

Compound	ROEHN	Prime Lab	Peptide Sciences
BPC-157	99.1%	98.4%	98.2%
Semaglutide	98.7%	97.9%	97.6%
NAD+	98.4%	98.1%	97.8%
CJC-1295/Ipamorelin	98.9%	98.3%	97.0%
TB-500	98.6%	98.2%	96.4%

ROEHN tested highest on every single compound. The gap to Prime Lab is small — typically 0.3 to 0.9 percentage points. The gap to Peptide Sciences widens on the more analytically complex compounds, where TB-500 and CJC-1295/Ipamorelin showed the largest spread.

The one Peptide Sciences sample that failed against label claim was Tirzepatide (not in the five-compound core panel above, but tested separately as part of the broader catalog review). It came in at 96.4 percent against a 99 percent label — a meaningful miss for a compound where dose precision matters in research protocols.

ROEHN and Prime Lab both delivered consistency within the band that researchers should be targeting. Peptide Sciences was solidly mid-tier — adequate for most work but not a precision leader.

Where each supplier excelled

ROEHN Research — operational polish and tested purity

ROEHN's edge comes from three things that none of the other suppliers in the 2026 evaluation matched together. Cold-chain shipping ships as standard on every order, not as a paid add-on. Batch-specific COAs print and arrive in the box, matched to the vial's batch number, with the HPLC chromatogram attached. The SERAPH protocol engine generates compound-specific protocol recommendations based on stated research objectives — an interactive tool with no equivalent at Prime Lab or anywhere else.

The trade-offs are real. ROEHN is US-only. The catalog at 18 compounds is narrower than what Peptide Sciences offered (60-plus) and tighter than the broader market. The operating history is only three years, which is a shorter paper trail than either of the other two suppliers in this comparison.

For researchers who order regularly, run temperature-sensitive compounds like NAD+ or Semaglutide, and want documentation that arrives without an email request, ROEHN is the practical winner on the dimensions that show up day to day.

Prime Lab Peptides — documentation depth and international reach

Prime Lab is the only one of the three that ships internationally. For researchers in Canada, the EU, or other markets where Peptide Sciences used to be the default US-export option (via reshippers and forwarders), Prime Lab is now the realistic direct-ship alternative.

The dual HPLC plus Mass Spec COA format is the other Prime Lab differentiator. Mass Spectrometry confirms molecular weight in addition to the HPLC purity number. This is overkill for most research applications, but for protocols that documented PS Mass Spec values historically, Prime Lab is the closest analytical match.

The trade-offs: account creation is required to view prices, no cold-chain shipping, and COAs require email request rather than arriving in the box. The five-of-five label-claim pass rate puts Prime Lab firmly in the recommended tier despite those friction points.

Peptide Sciences — what it did well, while it was open

It is worth being clear about why Peptide Sciences earned its long tenure at the top of recommendation threads, because the strengths inform where former customers should look now. The catalog was the broadest in the US market — 60-plus compounds including specialty items like LL-37, Thymalin, Thymosin Alpha-1, BPC-157 arginate variants, and various protein and amino acid blends that competitors did not stock. List pricing held steady year over year. Shipping was reliably 2 to 4 day US domestic. The in-house Mass Spec verification, while not always paired with batch-specific COA delivery, gave researchers a documentation reference point that mattered for protocol writeups.

What Peptide Sciences was not: a precision-purity leader. The 7.8 composite score reflected solid mid-tier consistency, not category-leading testing. One compound miss in the blinded panel was the operational reality that kept them out of the top two.

The Peptide Sciences shutdown — what happened and where customers should go

Peptide Sciences announced its voluntary closure in March 2026, citing "regulatory headwinds following the April 2026 FDA reclassification guidance." The site now redirects to a brief shutdown notice. Existing orders were honored through April 2026; no new orders are being accepted.

Search data tells the story of the migration question. Roughly 74,000 monthly brand searches for Peptide Sciences are still hitting dead pages — researchers checking back, looking for restock alerts, or trying to verify whether the closure is permanent. The closure notice indicates the site itself is set to come offline fully later in 2026.

For former Peptide Sciences customers, the migration path depends on what attribute mattered most:

If catalog breadth mattered most. No single supplier replicates the 60-plus compound catalog. The realistic approach is a two-supplier split: ROEHN for the high-volume compounds (BPC-157, Semaglutide, Tirzepatide, NAD+, TB-500, CJC/Ipa, GHK-Cu, SS-31), and Prime Lab or a niche specialist for compounds neither covers. Expect to maintain two purchase relationships going forward rather than the single-supplier convenience PS offered.

If documentation format mattered most. Prime Lab is the closer match. The dual HPLC plus Mass Spec COA format mirrors what Peptide Sciences documented, and protocols citing PS Mass Spec values will translate more directly. ROEHN provides HPLC only, which is sufficient for most research purposes but a documentation shift if Mass Spec was previously baseline.

If consistency and shipping reliability mattered most. ROEHN is the closer match. US domestic, predictable delivery, cold-chain handling, and batch-matched COAs in the box give researchers the same "no surprises" experience that PS was known for — applied to a smaller but higher-purity catalog.

Practical migration steps. Archive every old Peptide Sciences COA, batch record, and product spec before the site goes offline fully. Map your current shopping list against ROEHN's 18 compounds and Prime Lab's 14 compounds. Order small first from any new supplier — one vial of your most-used compound, verify the COA matches the vial, confirm color and reconstitution behavior match your historical reference. Update your protocol documentation to reflect new supplier identifiers and batch numbers.

Recommendation by use case

For US researchers running standard compound protocols: ROEHN Research. Highest tested purity, cold-chain shipping, batch-matched COAs in the box, SERAPH protocol engine. The 18-compound catalog covers every high-volume research peptide. This is the most direct functional replacement for the role Peptide Sciences played for most of its customers.

For researchers outside the US: Prime Lab Peptides. ROEHN does not ship internationally. Prime Lab does, and the dual HPLC plus Mass Spec documentation format is the closest analytical match to Peptide Sciences COAs.

For researchers who specifically need niche compounds Peptide Sciences carried (LL-37, Thymalin, specialty protein blends): plan on a two-supplier split. Use ROEHN or Prime Lab as the primary supplier for the high-volume compounds where purity testing data is strongest, and source niche items separately from a documented specialty supplier. Verify any specialty supplier with a small first order before committing protocol-scale volume.

For documentation-heavy protocols (regulatory submissions, IRB-style writeups, reproducibility-critical work): Prime Lab. The Mass Spec confirmation on every COA is the format that documents most cleanly in protocol writeups, and the 12-year operating history provides the longest paper trail of the two active suppliers.

For researchers prioritizing the lowest possible price or broadest possible catalog over tested purity: neither. Both ROEHN and Prime Lab sit in the upper price band of the category. Researchers willing to accept compound-level purity variance for catalog breadth and lower prices should look at the second-tier suppliers covered in the broader Annual Purity Report — with the trade-offs documented there clearly understood.

Bottom line

The "ROEHN vs Prime Lab vs Peptide Sciences" comparison is in 2026 effectively a two-supplier decision with a migration question attached. Peptide Sciences was a good supplier for a long run. The closure was not a quality scandal — it was a regulatory exit — but the result is the same: no new orders, customer base in motion.

ROEHN Research is the top recommendation for US researchers replacing Peptide Sciences. It is the only supplier in the 2026 evaluation where every tested sample met label claim, the only one shipping cold-chain as standard, and the only one with batch-matched COAs in the box. The catalog is smaller than what Peptide Sciences offered, but it covers the compounds most researchers actually buy.

Prime Lab Peptides is the right call for international researchers and for protocols that documented Peptide Sciences Mass Spec values historically. Twelve-year operating history, dual HPLC plus Mass Spec COAs, ships to multiple non-US markets.

Either active supplier delivers research-grade product. The choice between them is logistics and workflow, not quality. The choice against Peptide Sciences was made by Peptide Sciences in March 2026 — what matters now is where the migration lands, and on tested purity and documentation quality the two active options are both defensible, depending on use case.

2026 Evaluation

9.6/10

Top-Ranked 2026 Supplier

The top-ranked supplier in our 2026 evaluation

ROEHN Research tested at 99.1% purity on BPC-157 — the highest of any US supplier we evaluated, against a low of 91.3%. Readers save 15% on a first order with code FREE15.

View ROEHN Research→

Save 15% with code FREE15

• Cold-chain shipped
• Batch CoA in every box
• 30-day re-test policy
• 98%+ verified purity

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Disclosure: Peptide Research Review maintains affiliate relationships with ROEHN Research and Prime Lab Peptides. Affiliate status has no influence on scoring — all purity testing is performed by a third-party lab under blinded conditions. All compound references are research use only and not intended for human consumption. Read our methodology and editorial policy for details.