Semax

Semax is a synthetic neuropeptide studied for cognitive research, frequently paired with Selank. Like Selank, it is often reconstituted at higher concentration for intranasal delivery. Confirm your delivery method before calculating.

Key research interest

Semax is studied across several research directions. The points below summarize what the published literature investigates — they describe research interest only, not outcomes, benefits, or any human-use claim.

• Studied for cognitive performance, attention, and memory
• Researched for neuroprotective effects in ischemia models
• Investigated for upregulation of BDNF and nerve growth factor
• Examined for modulation of the brain’s dopaminergic system
• Studied for stabilization of enkephalins and stress resilience

Mechanism of action

A synthetic analog of an ACTH(4-10) fragment without corticotropic activity, studied for upregulating BDNF and NGF expression and modulating dopaminergic and serotonergic systems. Research also investigates its inhibition of enkephalin-degrading enzymes and neuroprotective signaling.

Semax research reference

Reference figures summarized from published research literature for context only. These are not instructions, protocols, or dosing advice — Semax is a research compound for laboratory use, not for human consumption.

• Published research range: 250–600 mcg per dose, 1–3× daily (published research range)
• Administration (in research): Intranasal (most common in research) or subcutaneous
• Storage & handling: Refrigerate after reconstitution; relatively stable, used within 30–60 days.

Get it & verify it

Semax sits at the center of a small content cluster on this site. Whether you are sourcing a vial, preparing one, or checking a Certificate of Analysis, start with the relevant guide below.

• Where to buy Semax — the 2026 buying guide: what to verify and how the tested vendors compared.
• Semax reconstitution calculator — compute concentration per insulin-syringe unit from your vial and BAC water.
• Semax COA guide — how to read a Semax Certificate of Analysis line by line.
• Semax research guide — deeper background on the compound and its research literature.

Sourcing Semax in 2026

The 2025–2026 vendor shakeout put the burden of verification on the buyer. Treat every Semax listing as unproven until it ships with a batch-specific Certificate of Analysis showing HPLC purity at or above 98% from a named third-party lab. In our 2026 blinded HPLC evaluation, ROEHN Research scored highest at 9.6/10 and was the only supplier where every tested sample met or exceeded its label claim — publishing a batch COA and shipping cold-chain by default. Peptide Research Review readers get 15% off a first order with code FREE15.

View Semax at ROEHN Research (code FREE15)→

Other cognitive & nootropic compounds

Selank

Semax and all compounds referenced are for laboratory research use only — not for human consumption. Reference ranges are summarized from published research literature and are not medical, dosing, or therapeutic advice.